The Fabrication of Titanium Alloy Biomedical Implants using Additive Manufacturing: A Way Forward

Authors

  • A.N. Aufa Razak Faculty of Technology and Informatics, Universiti Teknologi Malaysia, Jalan Sultan Yahya Petra, 54100 Kuala Lumpur, Malaysia
  • Mohamad Zaki Hassan Razak Faculty of Technology and Informatics, Universiti Teknologi Malaysia, Jalan Sultan Yahya Petra, 54100 Kuala Lumpur, Malaysia
  • Zarini Ismail Faculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia, Bandar Baru Nilai, 71800 Nilai, Negeri Sembilan, Malaysia

DOI:

https://doi.org/10.31437/2414-2115.2021.07.5

Keywords:

 Ti-6Al-4V, selective laser melting, additive manufacturing, osteointegration

Abstract

A biomedical implant is a man-made transplanted device used to replace missing life structures and support damaged biological hard tissue. The primary goal of these structures is to preserve the anatomical fixation of the human body. Currently, advanced titanium alloys occupy almost half of the market share of implant products however, they still pose concerns such as decreasing osteogenesis during application. This paper presents a review of the role of additive manufacturing (AM) in providing innovative methods for fabricating metallic alloys toward Industrial Revolution 4.0. Initially, an overview of biomedical implants is discussed, followed by an examination of the ability of titanium alloys produced using AM methods. Mechanical properties and other issues relating to the functional application of these biomedical implants are promptly discovered. Further, the effect of bone-implant contact between implants and tissues, which can lead to failure, while advanced methods to improve osteointegration through surface modification of the AM fabricated titanium alloys are also scrutinised.

References

Zhang LC, Chen LY. A Review on Biomedical Titanium Alloys: Recent Progress and Prospect. Advanced Engineering Materials 2019; 21(4): 1-29. https://doi.org/10.1002/adem.201801215

Teo AJT, Mishra A, Park I, Kim YJ, Park WT, Yoon YJ. Polymeric Biomaterials for Medical Implants and Devices. ACS Biomaterials Science and Engineering 2016; 2(4): 454- 72. https://doi.org/10.1021/acsbiomaterials.5b00429

Sionkowska A. Current research on the blends of natural and synthetic polymers as new biomaterials: Review. Progress in Polymer Science (Oxford) 2011; 36(9): 1254-76. https://doi.org/10.1016/j.progpolymsci.2011.05.003

Saini M, Singh Y, Arora P, Arora V, Jain K, Singh SM, et al. Implant biomaterials: A comprehensive review. A comprehensive review World J Clin Cases 2015; 3(1): 52-7. https://doi.org/10.12998/wjcc.v3.i1.52

Bosshardt DD, Chappuis V, Buser D. Osseointegration of titanium, titanium alloy and zirconia dental implants: current knowledge and open questions. Periodontology 2000 2017; 73(1): 22-40. https://doi.org/10.1111/prd.12179

Wang X, Xu S, Zhou S, Xu W, Leary M, Choong P, et al. Topological design and additive manufacturing of porous metals for bone scaffolds and orthopaedic implants: A review. Biomaterials 2016; 83: 127-41. https://doi.org/10.1016/j.biomaterials.2016.01.012

Liu W, Liu S, Wang L. Surface Modification of Biomedical Titanium Alloy: Micromorphology, Microstructure Evolution and Biomedical Applications. Coatings 2019; 9(4): 249. https://doi.org/10.3390/coatings9040249

Wang C, Hu H, Li Z, Shen Y, Xu Y, Zhang G, et al. Enhanced Osseointegration of Titanium Alloy Implants with Laser Microgrooved Surfaces and Graphene Oxide Coating. ACS Applied Materials and Interfaces 2019; 11(43): 39470- 83. https://doi.org/10.1021/acsami.9b12733

Saini M. Implant biomaterials: A comprehensive review. World Journal of Clinical Cases 2015; 3(1): 52. https://doi.org/10.12998/wjcc.v3.i1.52

Gallo J, Holinka M, Moucha CS. Antibacterial Surface Treatment for Orthopaedic Implants. OPEN ACCESS Int J Mol Sci 2014; 15: 15. https://doi.org/10.3390/ijms150813849

Zhang L-C, Chen L-Y, Wang L. Surface Modification of Titanium and Titanium Alloys: Technologies, Developments, and Future Interests. Advanced Engineering Materials 2020; 22(5). https://doi.org/10.1002/adem.201901258

Goriainov V, Cook R, Latham JM, Dunlop DG, Oreffo ROC. Bone and metal: An orthopaedic perspective on osseointegration of metals. Acta Biomaterialia 2014; 10(10): 4043-57. https://doi.org/10.1016/j.actbio.2014.06.004

Wang Q, Zhou P, Liu S, Attarilar S, Ma RLW, Zhong Y, et al. Multi-scale surface treatments of titanium implants for rapid osseointegration: A review. Nanomaterials 2020; 10(6): 1-27. https://doi.org/10.3390/nano10061244

Ibrahim MZ, Sarhan AAD, Yusuf F, Hamdi M. Biomedical materials and techniques to improve the tribological, mechanical and biomedical properties of orthopedic implants – A review article. Journal of Alloys and Compounds 2017; 714: 636-67. https://doi.org/10.1016/j.jallcom.2017.04.231

Chouirfa H, Bouloussa H, Migonney V, Falentin-Daudré C. Review of titanium surface modification techniques and coatings for antibacterial applications. Acta Biomaterialia 2019; 83: 37-54. https://doi.org/10.1016/j.actbio.2018.10.036

Zhang LC, Liu Y, Li S, Hao Y. Additive Manufacturing of Titanium Alloys by Electron Beam Melting: A Review. Advanced Engineering Materials 2018; 20(5): 1-16. https://doi.org/10.1002/adem.201700842

Attaran M. The rise of 3-D printing: The advantages of additive manufacturing over traditional manufacturing. Business Horizons 2017; 60(5): 677-88. https://doi.org/10.1016/j.bushor.2017.05.011

Tofail SAM, Koumoulos EP, Bandyopadhyay A, Bose S, O'Donoghue L, Charitidis C. Additive manufacturing: scientific and technological challenges, market uptake and opportunities. Materials Today 2018; 21(1): 22-37. https://doi.org/10.1016/j.mattod.2017.07.001

DebRoy T, Wei HL, Zuback JS, Mukherjee T, Elmer JW, Milewski JO, et al. Additive manufacturing of metallic components – Process, structure and properties. Progress in Materials Science 2018; 92: 112-224. https://doi.org/10.1016/j.pmatsci.2017.10.001

Liu S, Shin YC. Additive manufacturing of Ti6Al4V alloy: A review. Materials and Design 2019; 164: 107552. https://doi.org/10.1016/j.matdes.2018.107552

Sidambe AT. Biocompatibility of advanced manufactured titanium implants-A review. Materials 2014; 7(12): 8168-88. https://doi.org/10.3390/ma7128168

Zadpoor AA, Malda J. Additive Manufacturing of Biomaterials, Tissues, and Organs. Annals of Biomedical Engineering 2017; 45(1): 1-11. https://doi.org/10.1007/s10439-016-1719-y

Davis N, Schwab K. Shaping the Future of the Fourth Industrial Revolution2018.

Ligon SC, Liska R, Stampfl J, Gurr M, Mu?lhaupt R. Polymers for 3D Printing and Customized Additive Manufacturing. Chemical Reviews 2017; 117(15): 10212-90. https://doi.org/10.1021/acs.chemrev.7b00074

Agius D, Kourousis KI, Wallbrink C. A review of the as-built SLM Ti-6Al-4V mechanical properties towards achieving fatigue resistant designs. Metals 2018; 8(1). https://doi.org/10.3390/met8010075

Zhang LC, Attar H, Calin M, Eckert J. Review on manufacture by selective laser melting and properties of titanium based materials for biomedical applications. Materials Technology 2016; 31(2): 66-76. https://doi.org/10.1179/1753555715Y.0000000076

Bourell D, Kruth JP, Leu M, Levy G, Rosen D, Beese AM, et al. Materials for additive manufacturing. CIRP Annals - Manufacturing Technology 2017; 66(2): 659-81. https://doi.org/10.1016/j.cirp.2017.05.009

Prakash C, Singh S, Pruncu CI, Mishra V, Królczyk G, Pimenov DY, et al. Surface modification of Ti-6Al-4V alloy by electrical discharge coating process using partially sintered Ti-Nb electrode. Materials 2019; 12(7). https://doi.org/10.3390/ma12071006

Eisenbarth E, Velten D, Mu?ller M, Thull R, Breme J. Biocompatibility of ? -stabilizing elements of titanium alloys. Biomaterials 2004; 25(26): 5705-13. https://doi.org/10.1016/j.biomaterials.2004.01.021

Sing SL, Tey CF, Tan JHK, Huang S, Yeong WY. 2 - 3D printing of metals in rapid prototyping of biomaterials: Techniques in additive manufacturing. In: Narayan R, editor. Rapid Prototyping of Biomaterials (Second Edition): Woodhead Publishing; 2020. p. 17-40. https://doi.org/10.1016/B978-0-08-102663-2.00002-2

Nandwana P, Elliott AM, Siddel D, Merriman A, Peter WH, Babu SS. Powder bed binder jet 3D printing of Inconel 718: Densification, microstructural evolution and challenges?. Current Opinion in Solid State and Materials Science 2017; 21(4): 207-18. https://doi.org/10.1016/j.cossms.2016.12.002

Yap CY, Chua CK, Dong ZL, Liu ZH, Zhang DQ, Loh LE, et al. Review of selective laser melting: Materials and applications. Applied Physics Reviews 2015; 2(4). https://doi.org/10.1063/1.4935926

Jiao L, Chua ZY, Moon SK, Song J, Bi G, Zheng H. Femtosecond Laser Produced Hydrophobic Hierarchical Structures on Additive Manufacturing Parts. Nanomaterials 2018; 8(8): 601. https://doi.org/10.3390/nano8080601

Sadali MF, Hassan MZ. In fl uence of selective laser melting scanning speed parameter on the surface morphology , surface roughness , and micropores for manufactured Ti6Al4V parts 2020: 1-11. https://doi.org/10.1557/jmr.2020.84

Xiao L, Song W, Hu M, Li P. Compressive properties and micro-structural characteristics of Ti–6Al–4V fabricated by electron beam melting and selective laser melting. Materials Science and Engineering: A 2019; 764. https://doi.org/10.1016/j.msea.2019.138204

Ginestra P, Ferraro RM, Zohar-Hauber K, Abeni A, Giliani S, Ceretti E. Selective Laser Melting and Electron Beam Melting of Ti6Al4V for Orthopedic Applications: A Comparative Study on the Applied Building Direction. Materials (Basel) 2020; 13(23). https://doi.org/10.3390/ma13235584

Singh N, Hameed P, Ummethala R, Manivasagam G, Prashanth KG. Selective laser manufacturing of Ti-based alloys and composites: impact of process parameters , application trends , and future prospects. Materials Today Advances 2020; 8: 100097. https://doi.org/10.1016/j.mtadv.2020.100097

Asri RIM, Harun WSW, Samykano M, Lah NAC, Ghani SAC, Tarlochan F, et al. Corrosion and surface modification on biocompatible metals: A review. Materials Science and Engineering C 2017; 77: 1261-74. https://doi.org/10.1016/j.msec.2017.04.102

Tsukanaka M, Fujibayashi S, Takemoto M, Matsushita T, Kokubo T, Nakamura T, et al. Bioactive treatment promotes osteoblast differentiation on titanium materials fabricated by selective laser melting technology. Dent Mater J 2016; 35(1): 118-25. https://doi.org/10.4012/dmj.2015-127

Zhang BL-c, Attar H. Selective Laser Melting of Titanium Alloys and Titanium Matrix Composites for Biomedical Applications: A Review ** 2016(4): 463-75. https://doi.org/10.1002/adem.201500419

Spears TG, Gold SA. In-process sensing in selective laser melting (SLM) additive manufacturing. Integrating Materials and Manufacturing Innovation 2016; 5(1): 16-40. https://doi.org/10.1186/s40192-016-0045-4

Bose S, Vahabzadeh S, Bandyopadhyay A. Bone tissue engineering using 3D printing. Materials Today 2013; 16(12): 496-504. https://doi.org/10.1016/j.mattod.2013.11.017

Zhang LC, Chen LY, Wang L. Surface Modification of Titanium and Titanium Alloys: Technologies, Developments, and Future Interests. Advanced Engineering Materials 2020; 22(5): 1-37. https://doi.org/10.1002/adem.202070017

Bandyopadhyay A, Heer B. Additive manufacturing of multimaterial structures. Materials Science and Engineering R: Reports 2018; 129(April): 1-16. https://doi.org/10.1016/j.mser.2018.04.001

Virginia Sáenz de V, Elena F. Titanium and Titanium Alloys as Biomaterials, Tribology - Fundamentals and Advancements. Tribology - Fundamentals and Advancements 2013; 55(112005): 561-5.

Bandyopadhyay A, Espana F, Balla VK, Bose S, Ohgami Y, Davies NM. Influence of porosity on mechanical properties and in vivo response of Ti6Al4V implants. Acta Biomater 2010; 6(4): 1640-8. https://doi.org/10.1016/j.actbio.2009.11.011

Wang Z, Wang C, Li C, Qin Y, Zhong L, Chen B, et al. Analysis of factors influencing bone ingrowth into threedimensional printed porous metal scaffolds: A review. Journal of Alloys and Compounds 2017; 717: 271-85. https://doi.org/10.1016/j.jallcom.2017.05.079

Mohd Faizal Sadali MZH, Nurul Huda Ahmad, Mohamed Azlan Suhot, Roslina Mohammad. Laser power implication to the hardness of Ti-6Al-4V powder by using SLM additive manufacturing technology. Proceedings of Mechanical Engineering Research Day 2020 2020.

Sadali MF. Effect of Hatching Distance on Surface Morphology and Surface Roughness of the Ti6Al4V for Biomedical Implant using SLM Process. Malaysian Journal of Microscopy 2019; 15: 72-82.

Zhao D, Huang Y, Ao Y, Han C, Wang Q, Li Y, et al. Effect of pore geometry on the fatigue properties and cell affinity of porous titanium scaffolds fabricated by selective laser melting. J Mech Behav Biomed Mater 2018; 88: 478-87. https://doi.org/10.1016/j.jmbbm.2018.08.048

Zhang B, Li Y, Bai Q. Defect Formation Mechanisms in Selective Laser Melting: A Review. Chinese Journal of Mechanical Engineering (English Edition) 2017; 30(3): 515- 27. https://doi.org/10.1007/s10033-017-0121-5

Sugawara Y, Kamioka H, Honjo T, Tezuka K, Takano- Yamamoto T. Three-dimensional reconstruction of chick calvarial osteocytes and their cell processes using confocal microscopy. Bone 2005; 36(5): 877-83. https://doi.org/10.1016/j.bone.2004.10.008

Fukuda A, Takemoto M, Saito T, Fujibayashi S, Neo M, Pattanayak DK, et al. Osteoinduction of porous Ti implants with a channel structure fabricated by selective laser melting. Acta Biomater 2011; 7(5): 2327-36. https://doi.org/10.1016/j.actbio.2011.01.037

Marsell R, Einhorn TA. The biology of fracture healing. Injury 2011; 42(6): 551-5. https://doi.org/10.1016/j.injury.2011.03.031

Abbasi N, Hamlet S, Love RM, Nguyen N-T. Porous scaffolds for bone regeneration. Journal of Science: Advanced Materials and Devices 2020; 5(1): 1-9. https://doi.org/10.1016/j.jsamd.2020.01.007

Attar H, Calin M, Zhang LC, Scudino S, Eckert J. Manufacture by selective laser melting and mechanical behavior of commercially pure titanium. Materials Science and Engineering A 2014; 593: 170-7. https://doi.org/10.1016/j.msea.2013.11.038

Publishing SM. Additive Manufacturing in Orthopedics Projected to Grow at 27 Percent Annually Per Latest SmarTech Analysis Study

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2021-05-05

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